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Anti-Tau (Phospho–Thr181) Mouse mAb
- Suitable for WB, ELISA, IP
- Reacts with Human, Mouse
| Description Microtubule-associated protein tau (MAPT) promotes microtubule assembly and stability and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311/32961270). In Alzheimer’s disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer’s disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylation. | ||
| Species Reactivity | Human, Mouse | |
| Application | WB, ELISA, IP | |
| Isotype | Mouse IgG1 Kappa | |
| Antibody Type | Monoclonal antibody | |
| Immunogen | Synthetic phosphorylated peptide | |
| Form | Liquid | |
| Formulation | Phosphate-buffered solution; no preservatives or carrier proteins. | |
| Preparation | The antibody was purified by affnity chromatography. | |
| Purity | SDS-PAGE > 95% | |
| Concentration | 0.5 mg/mL | |
| Endotoxin | 0-1EU/mg | |
| Storage Conditions | Store at 2°C to 8°C short term (1-2 weeks). Store at -80°C long term (36 months). Avoid thaw and freeze cycle. | |
| Shipping Conditions | Ambient (domestic); Wet ice (international) | |
| Limitations | Our products are to be used for Research Use Only. | |
| Data Sheet | ▼ Safety Data Sheet (SDS) ▼ Data Sheet ▼ CoA | |
